Ipamorelin
A profile on the cleanest Growth Hormone Secretagogue, known for stimulating GH release without significant cortisol or prolactin spikes.
Ipamorelin
Ipamorelin is a selective Growth Hormone Secretagogue (GHS) and a ghrelin receptor agonist. It belongs to the GHRP (Growth Hormone Releasing Peptide) class.
It is widely favored in the anti-aging and bodybuilding communities because it is the "cleanest" GHRP. Unlike GHRP-6 or GHRP-2, Ipamorelin stimulates the release of growth hormone with virtually no impact on cortisol or prolactin levels and minimal appetite stimulation.
Quick Specs
| Property | Value |
|---|---|
| Active Compound | Ipamorelin |
| Half-Life | ~2 Hours |
| Mechanism | Selective GH Secretagogue |
| Administration | Subcutaneous (SubQ) |
Mechanism of Action
Ipamorelin binds to the ghrelin receptor in the pituitary gland, triggering a strong pulse of Growth Hormone.
Crucially, it is highly selective. While other peptides in this class hits the "gas pedal" for GH, Cortisol, and Prolactin simultaneously, Ipamorelin hits the gas for GH only. This makes it ideal for long-term use.
Pharmacokinetics & Dosing
Dosing Protocol
Because of its short half-life and pulsatile nature, timing is key.
- Dosage: 100mcg - 300mcg per injection.
- Frequency: 2-3 times daily.
- Morning: Fasted.
- Post-Workout: To capitalize on the natural GH spike.
- Pre-Bed: The most important dose for sleep and recovery.
- The Stack: Almost always stacked with CJC-1295 (No DAC). The combination creates a synergistic effect where the pulse is both stronger and lasts longer.
Primary Effects
1. Fat Loss & Lean Mass
Increases lipolysis and protein synthesis via elevated IGF-1 levels.
2. Sleep Quality
One of the most reported benefits is deeper, more restorative sleep.
3. Anti-Aging
Improves skin collagen density and joint health over time.
Side Effects & Harm Reduction
Safety Profile:
The Gentle Peptide: Ipamorelin has very few side effects. It does not cause the "hunger pangs" of GHRP-6 or the "jittery" feelings of Hexarelin.
1. Head Rush
A mild flushing or head rush may occur immediately after injection due to vasodilation.
2. Injection Site
Mild redness or itching at the pin site is possible.
Tracking Ipamorelin
Using the Anabolic Tracker app:
- Inventory: Add Ipamorelin.
- Scheduling: Twice or Three Times Daily.
- Metrics: Track Sleep Quality and Body Fat %.
- Notes: If stacking with CJC-1295, note that in the compound name (e.g., "Ipa/CJC Stack").
Disclaimer:
This guide is for informational purposes only. Ipamorelin is a research chemical.