Tirzepatide
A profile on the dual GIP/GLP-1 agonist (Mounjaro), offering even greater weight loss potential than Semaglutide.
Tirzepatide
Tirzepatide (Mounjaro/Zepbound) is the "big brother" to Semaglutide. It is the first drug in a new class of dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonists.
Clinical trials have shown it to be significantly more effective for weight loss than Semaglutide, with some patients losing over 20% of their body weight.
Quick Specs
| Property | Value |
|---|---|
| Active Compound | Tirzepatide |
| Half-Life | ~5 Days |
| Mechanism | Dual GIP / GLP-1 Agonist |
| Administration | Subcutaneous (SubQ) |
Mechanism of Action
While Semaglutide only hits the GLP-1 receptor, Tirzepatide hits both GLP-1 and GIP receptors.
- GLP-1: Reduces appetite, slows digestion.
- GIP: Enhances insulin release and improves lipid metabolism.
This dual action appears to improve the tolerability (less nausea) while increasing the metabolic benefits compared to GLP-1 alone.
Pharmacokinetics & Dosing
Half-Life: ~5 Days
- Frequency: Once Weekly (usually).
- Titration: Similar to Semaglutide, start low.
- Start: 2.5mg weekly.
- Increase: By 2.5mg every 4 weeks.
- Max: 15mg weekly.
Primary Effects
1. Massive Weight Loss
Currently the most potent non-stimulant fat loss agent available.
2. Metabolic Health
Drastic improvements in HbA1c, lipids, and blood pressure.
Side Effects & Harm Reduction
Cost vs Benefit:
Potency: Tirzepatide is stronger than Semaglutide. If Semaglutide works for you, there is no need to switch. Tirzepatide is typically reserved for those who plateau on Semaglutide.
1. GI Distress
Nausea, diarrhea, and constipation are common, though anecdotal reports suggest less nausea than Semaglutide.
2. Hypoglycemia
Because it powerfully drives insulin, low blood sugar can occur if you don't eat anything for long periods.
Tracking Tirzepatide
Using the Anabolic Tracker app:
- Inventory: Add Tirzepatide.
- Scheduling: Once Weekly.
- Metrics: Track Body Weight.
- Notes: Monitor bowel movements. Constipation is a common issue with these peptides; hydration and fiber are key.
Disclaimer:
This guide is for informational purposes only. Tirzepatide is a prescription medication.