Semax
A profile on the premier Russian nootropic peptide, used for stroke recovery, cognitive enhancement, and ADHD.
Semax
Semax is a synthetic peptide derived from a fragment of Adrenocorticotropic Hormone (ACTH 4-10). Like Selank, it was developed in Russia and is on their List of Vital & Essential Drugs.
It is a powerful stimulatory nootropic. It increases focus, learning capacity, and memory without the jittery physical side effects of amphetamines or caffeine.
Quick Specs
| Property | Value |
|---|---|
| Active Compound | Met-Glu-His-Phe-Pro-Gly-Pro |
| Half-Life | Short (Effects last 4-6 hours) |
| Mechanism | BDNF / Dopamine / Serotonin Modulation |
| Administration | Intranasal (Spray) or SubQ |
Mechanism of Action
- Neurotrophic: Rapidly increases levels of BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor). This supports neuron survival and growth.
- Neurotransmitters: Increases the turnover of dopamine and serotonin, improving mood and focus.
- Neuroprotection: Protects the brain from hypoxia (lack of oxygen). This is why it is used by Russian paramedics for stroke victims.
Pharmacokinetics & Dosing
Forms
- Semax: The standard version.
- N-Acetyl Semax: Greater ability to cross the blood-brain barrier.
- Adamax: The most potent derivative (covered in a separate profile).
Dosing Protocol
- Intranasal: 2 sprays per nostril, 2-3 times daily.
- SubQ Injection: 100mcg - 300mcg per day.
- Timing: Take in the Morning. Taking it late will prevent sleep due to mental stimulation.
Primary Effects
1. Focus & Flow
Induces a state of clear, sharp mental energy. Great for complex tasks or studying.
2. Mood Elevation
Mild antidepressant effects due to dopamine/serotonin modulation.
3. Memory
Improves short-term memory recall and processing speed.
Side Effects & Harm Reduction
Hair Loss?:
BDNF Link: There is a theoretical link between high BDNF levels and hair shedding (similar to stress shedding). While rare, some users report hair thinning on extended Semax cycles.
1. Overstimulation
Can cause irritability or "wired" feelings if dosed too high.
2. Tolerance
Tolerance can build. It is recommended to cycle Semax (e.g., 4 weeks on, 2 weeks off).
Tracking Semax
Using the Anabolic Tracker app:
- Inventory: Add Semax.
- Scheduling: Daily (AM).
- Metrics: Track Productivity and Focus.
Disclaimer:
This guide is for informational purposes only. Semax is a prescription drug in Russia.