ACP-105
A profile on ACP-105, a SARM designed to improve strength and endurance with a minimal side effect profile, often compared to Ostarine and S4.
ACP-105
ACP-105 is a novel SARM developed by Acadia Pharmaceuticals. It was designed to treat degenerative bone and muscle disorders.
It sits in a "sweet spot" for many researchers: it is stronger than Ostarine (MK-2866) but carries fewer side effects than RAD-140 or LGD-4033. It is particularly noted for providing a hard, vascular look and significant endurance improvements without the vision side effects associated with S4 (Andarine).
Quick Specs
| Property | Value |
|---|---|
| Active Compound | ACP-105 |
| Half-Life | ~4-6 Hours |
| Detection Time | Unknown |
| Anabolic/Androgenic Ratio | 3.19 : 1 (Relative to Testosterone) |
| Chemical Family | SARM |
| Administration | Oral |
Mechanism of Action
ACP-105 is a partial agonist. It binds to the androgen receptor with high affinity. One of its unique characteristics is its interaction with radiation; studies showed it could protect muscle mass even in the presence of ionizing radiation, highlighting its potent anti-catabolic nature.
Pharmacokinetics & Dosing
Half-Life: ~4-6 Hours
Short half-life requires split dosing.
- Frequency: 2-3 times daily.
- Dosage: 10mg to 20mg per day.
- Duration: 8-10 weeks.
Primary Effects
1. Vascularity & Hardness
Users often report a rapid drying-out effect, leading to increased vein visibility and muscle density.
2. Endurance
Similar to Cardarine (though via a different mechanism), ACP-105 boosts workout stamina and recovery between sets.
3. Strength to Weight Ratio
Excellent for athletes who need to get stronger without moving up a weight class.
Side Effects & Harm Reduction
Headaches:
Side Effect: A commonly reported specific side effect of ACP-105 is mild headaches upon starting the cycle. This usually subsides after the first week or with increased hydration.
1. Suppression
It is suppressive to the HPTA axis. While often claimed to be "safer" than RAD-140, bloodwork consistently shows drops in Total Testosterone and SHBG. PCT is required.
2. Lipid Profile
Expect a reduction in HDL cholesterol levels.
Tracking ACP-105
Using the Anabolic Tracker app:
- Inventory: Add ACP-105.
- Scheduling: Three Times Daily (Breakfast, Lunch, Dinner).
- Metrics: Track Cardio Performance or Resting Heart Rate.
Disclaimer:
This guide is for informational purposes only. ACP-105 is an investigational drug.