LGD-3303
A profile on the "dry" cousin of Ligandrol, known for providing a harder, grainier look but requiring frequent dosing.
LGD-3303
LGD-3303 is a selective androgen receptor modulator (SARM) developed by Ligand Pharmaceuticals. While it shares a similar name to LGD-4033 (Ligandrol), its effects are quite different.
LGD-4033 is known for "wet" mass and size. LGD-3303 is known for "dry" gains, muscle hardness, and strength, often drawing comparisons to Winstrol or Anavar in the SARM world.
Quick Specs
| Property | Value |
|---|---|
| Active Compound | LGD-3303 |
| Half-Life | ~6 Hours |
| Detection Time | Unknown |
| Anabolic/Androgenic Ratio | High : Low |
| Chemical Family | SARM |
| Administration | Oral |
Mechanism of Action
It is a full agonist of the androgen receptor in skeletal muscle and bone, with high selectivity (sparing the prostate). It creates a very nitrogen-positive environment conducive to muscle hypertrophy without water retention.
Pharmacokinetics & Dosing
Half-Life: ~6 Hours
This is the main drawback of LGD-3303 compared to LGD-4033.
- Frequency: Must be dosed 3-4 times per day to maintain stable blood levels.
- Dosage: 10mg to 20mg per day total (split into smaller doses).
Primary Effects
1. Muscle Hardness
Produces a dense, grainy look to the muscle. Excellent for finishing a cutting cycle.
2. Strength
Potent strength gains, often exceeding those of Ostarine or S4.
3. Bone Density
Originally researched for osteoporosis, it significantly increases bone mineral density.
Side Effects & Harm Reduction
Suppression:
HPTA Shutdown: LGD-3303 is considered one of the more suppressive SARMs. Testosterone suppression will occur quickly. A full PCT (Post Cycle Therapy) is mandatory. Some users run it with a "Test Base" (like TRT or Enclomiphene) to prevent lethargy.
1. Dry Joints
Like Winstrol, the drying effect can sometimes lead to joint discomfort.
2. Lipid Profile
Expect a drop in HDL cholesterol.
Tracking LGD-3303
Using the Anabolic Tracker app:
- Inventory: Add LGD-3303.
- Scheduling: Three Times Daily (e.g., 8am, 2pm, 8pm).
- Metrics: Track Muscle Hardness and Joint Pain.
Disclaimer:
This guide is for informational purposes only. LGD-3303 is a research chemical.