Ligandrol (LGD-4033)

Ligandrol (LGD-4033, now VK5211) is arguably the most popular mass-building SARM. It was developed by Ligand Pharmaceuticals to treat conditions like muscle wasting and osteoporosis.

In bodybuilding, it is the go-to SARM for bulking. It is significantly stronger than Ostarine and provides "wet" gains, meaning it adds fullness and size rapidly, though some of this is water retention.

Quick Specs

Mechanism of Action

LGD-4033 binds selectively to androgen receptors in bone and muscle tissue. It has a very high affinity for the AR. It signals the body to build muscle and strengthen bone without heavily affecting the prostate or sebaceous glands.

Pharmacokinetics & Dosing

Half-Life: ~24-36 Hours

It has a very convenient half-life.

• Frequency: Once Daily dosing is perfectly sufficient.
• Dosage:
  • Beginner: 5mg/day.
  • Advanced: 10mg/day.
  • Note: Clinical trials showed measurable muscle gain at doses as low as 1mg. Diminishing returns hit hard past 10mg.

Primary Effects

1. Mass Gain

Users can gain significant lean body mass (5-10 lbs) in a cycle. Muscles look full and round due to glycogen and water retention.

2. Strength

Strength increases are reliable and noticeable within the first 2 weeks.

3. Bone Health

Increases bone mineral density significantly.

Side Effects & Harm Reduction

1. Water Retention

Unlike RAD-140 or S4, LGD can cause some bloating. Monitor sodium intake and blood pressure.

2. "LGD Flu"

Some users report feeling sick (upper respiratory symptoms) during the first week of use.

3. Lipids

HDL cholesterol will drop. Cardio and Omega-3s are important.

Tracking Ligandrol

Using the Anabolic Tracker app:

1. Inventory: Add Ligandrol (LGD-4033).
2. Scheduling: Daily.
3. Metrics: Track Weight and Blood Pressure (due to water retention).
4. Cycle Length: Typically 8 weeks.