Hexarelin
A profile on the strongest GHRP available, known for massive GH release but rapid receptor desensitization.
Hexarelin
Hexarelin is a synthetic Growth Hormone Releasing Peptide (GHRP). Structurally, it is similar to GHRP-6, but it is significantly more potent.
It is widely considered the strongest GH secretagogue on a mg-per-mg basis. It triggers a massive pulse of HGH. However, this power comes at a cost: it causes rapid desensitization (tolerance) and significantly elevates cortisol and prolactin.
Quick Specs
| Property | Value |
|---|---|
| Active Compound | Hexarelin |
| Half-Life | ~1 Hour |
| Mechanism | GH Secretagogue |
| Administration | Subcutaneous (SubQ) |
Mechanism of Action
Hexarelin binds to the ghrelin receptor and the CD36 receptor.
- GH Release: Signals the largest possible immediate release of GH stores from the pituitary.
- Cardioprotection: Uniquely, its interaction with CD36 receptors on the heart offers cardioprotective properties (improving cardiac output), distinct from other GHRPs.
Pharmacokinetics & Dosing
Dosing Protocol
- Dosage: 100mcg - 200mcg per injection.
- Frequency: 1-2 times daily.
- Cycle Limit: Max 4 weeks.
- Why? The pituitary stops responding to Hexarelin very quickly. After 4 weeks, it effectively stops working. A 4-week break is required.
Primary Effects
1. Mass & Strength
Due to the sheer volume of GH and IGF-1 released, it is the best GHRP for sheer mass gain and strength.
2. Healing
Rapid repair of tissues due to the massive GH spike.
3. No Appetite
Unlike GHRP-6, Hexarelin does not drastically increase appetite, making it usable during a cut.
Side Effects & Harm Reduction
Hormone Spike:
Cortisol & Prolactin: Hexarelin causes the sharpest spike in stress hormones of all GHRPs. This can lead to water retention, anxiety, and gyno issues. Do not use if you are sensitive to these side effects.
1. Desensitization
Long-term use is futile. It is a "blasting" peptide, not a maintenance one.
2. Sleep Disturbance
Because it raises cortisol, injecting it right before bed can sometimes disrupt sleep rather than help it (unlike Ipamorelin).
Tracking Hexarelin
Using the Anabolic Tracker app:
- Inventory: Add Hexarelin.
- Scheduling: Daily.
- Metrics: Track Strength and Recovery.
- Duration: Set a strict 4-week cycle end date.
Disclaimer:
This guide is for informational purposes only. Hexarelin is a research chemical.