Melanotan I

Melanotan I (Afamelanotide) is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). It is the predecessor to Melanotan II.

While Melanotan II is famous for rapid results and heavy side effects (nausea, unwanted erections), Melanotan I is much more selective. It stimulates tanning (melanogenesis) without crossing the blood-brain barrier as aggressively, resulting in a much cleaner experience.

Quick Specs

Mechanism of Action

Melanotan I binds primarily to the MC1 receptor (located in the skin).

• Selectivity: It has very low affinity for the MC3/MC4 receptors in the brain, which are responsible for the appetite suppression and sexual arousal/nausea effects seen with Melanotan II.
• Result: It produces melanin (tan) without messing with your brain chemistry.

Pharmacokinetics & Dosing

Dosing Protocol

Melanotan I is less potent than MT2, requiring higher doses and longer duration to work.

• Dosage: 1mg - 2mg per day. (Compare to MT2's 0.25mg).
• Frequency: Daily during loading phase.
• Duration: It may take 3-4 weeks to see significant tanning, compared to 1 week with MT2.

Primary Effects

1. Tanning

Increases the skin's tolerance to UV rays and darkens pigmentation.

2. Photoprotection

Clinically approved (as Scenesse) to treat erythropoietic protoporphyria (EPP), a condition where sunlight causes pain. It protects skin from burning.

Side Effects & Harm Reduction

1. Slow Onset

Patience is required. Do not increase the dose just because you aren't brown in 3 days.

Tracking Melanotan I

Using the Anabolic Tracker app:

1. Inventory: Add Melanotan I.
2. Scheduling: Daily.
3. Metrics: Track Skin Tone (Photos).